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In the introduction, Stephen
Gislason MD writes: 'The subject of food allergy
is fascinating from many points of view. In my opinion, it is one of the more
important topics in the study of practical medicine and one of the most
ignored. The
ignorance of delayed patterns of food allergy among physicians is embarrassing. Official denial is
understandable, since many powerful vested interests are threatened by the
possibility that food allergy is a cause of common of endemic diseases. Denial
is the best defense if you are marketing foods that cause disease, but are
generally considered to be "safe foods."
This
collection of abstracts and references is part of an introduction to the study of
food allergy recommended to all who are interested in the food causes of
disease. The theory and practice are discussed in The Book of Allergy and
Immunology; the abstracts are supplementary to this text. This volume also
lists references papers published before 1985 that establish the concept of
delayed patterns of food allergy and provide scientific evidence of mechanisms
of immune mediated disease that may underlie the most common and most unsolved
disease processes.
There are rich leads for
further research, good insights for clinicians, and a good resource for
patients and their families who usually have solve food-related diseases on
their own.
Sicher et in the first abstract of this collection provide us with a
good introduction to the papers that follow:
Determinants of systemic manifestations of
food allergy
J Allergy Clin Immunol 2000
Nov;106(5 Suppl):S251-7
Sicherer SH . Elliot and Roslyn Jaffe Food Allergy Institute, Division of
Allergy and Immunology, Department of Pediatrics, Mount Sinai School of
Medicine, New York, NY, USA.
"The myriad of systemic
manifestations induced by food hypersensitivity responses is testament to the
ability of localized exposure to foods in the gastrointestinal tract to result
in symptoms in distal target organs. Cow's milk protein, for example, may
induce hives (urticaria), atopic dermatitis, isolated gastrointestinal
symptoms, or severe generalized anaphylaxis in different individuals or in the
same person at different times. These diverse manifestations are the result of
complex interactions among the causal food protein, gut, immune system, and
target organs. The dynamic state of these interactions is demonstrated by the
development of food tolerance in most subjects and by the ability to
experience the development of new allergies in some subjects. This review
explores the variety of clinical manifestations of food hypersensitivity
disorders in the context of the question: What determines the local or
systemic expression of food allergy in a given individual at a particular
time? Evidence is provided for both systemic and local immune activation. The
role of food-protein chemistry, absorption and processing of ingested
allergen, immune responses (type, degree, and specificity), and target organ
hyperreactivity are considered as determinants in the expression of food
allergic disorders.
Printed Text Version is $22.95; 120 pages.
April 2004
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