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Parents need to know two basic principles of
gastrointestinal tract management:
1. If you don't like what comes out - change what goes in.
2. Treat symptoms as information. When the gastrointestinal tract
complains, adjust your child's food intake until the complaints disappear.
The most common infant digestive problems are
- colic
- constipation
-
diarrhea.
All three may occur together. All three are likely to be food-related. The
"irritable" or reactive bowel syndrome begins in infancy with colic, bloating,
regurgitation, vomiting and diarrhea. Colic in infancy is abdominal pain with the
attendant emotional distress of the infant and his parents.
Jenkins et al demonstrated that food allergy is a major cause of infantile colitis.
Gastrointestinal symptoms are often associated with:
- rhinorrhea (nose congestion, runny nose)
- cough, dyspnea and bronchospasm (asthma)
- eczema, urticaria, and angioedema. ( eczema and hives )
The combination of gastrointestinal symptoms with congestion, cough, hives, and/or
eczema should suggest the diagnosis of food allergy until proven otherwise. The food
allergy is likely to be the delayed pattern and will not reliably show up on skin or RAST
tests. The diagnosis must be confirmed by proper diet revision, which will resolve the
problem if food-related.
The gastrointestinal tract is a sensing, reactive device that monitors the material
flowing through it. Symptoms arising from this system provide information about its
dysfunction. Seven basic symptoms signal gastrointestinal tract displeasure with food
choices - nausea, heartburn, vomiting, bloating, pain, constipation and diarrhea.
Food allergy-intolerance is associated with almost every conceivable pain pattern, but
is most often associated with bloating and changes in stool consistency and/or frequency.
Episodes of crampy abdominal pain with diarrhea are often food-related and may be
diagnosed as "food-poisoning" if infrequent. Mothers often notice abdominal
distention in younger children. Symptoms arising from the gastrointestinal tract can
mean:
-
Problems with the food supply that trigger gastrointestinal tract responses
-
Problems down-stream in the body if food antigens enter through an overly permeable
gastrointestinal tract
Breast-fed infants are exposed to food allergy through their mothers' milk. Harmatz and
Bloch stated that: "Infants presenting with manifestations of atopic disease
including atopic dermatitis, colic, colitis, or diarrhea and with exclusive breast feeding
should be considered to have maternal diet protein-related disease."
In their review of the passage on food proteins into mother's milk they stated that
measurements of IgE responses (total IgE, IgE RAST and skin tests) were not helpful
diagnosing infants who had symptoms from breast milk. Jacobsson and Lindberg demonstrated
that cow's milk in the maternal diet can cause colic in breast-fed infants. Lothe et al
demonstrated that infantile colic is a symptom of cows milk protein intolerance and
remitted when a cows milk formula was replaced with nutramigen, a hypoallergenic formula,
based on hydrolysed casein. mahjong games
A mother may have to retreat to a hypoallergenic diet to rescue her infant from colic
with or without more obvious manifestations of food allergy. Adequate nutrition can be
supplied by Phase 1 foods (see Alpha Nutrition) during
the 10 days required to clear her infant's symptoms. Exclusion of single high risk food
groups such as milk and eggs may not be adequate to solve the infant's problem. Once the
infant is comfortable, mother may then reintroduce low risk foods and expand her diet,
monitoring her infant for recurrent symptoms.
Diarrhea - Acute Infections
Bout of diarrhea are common in toddlers for food borne infections. In third-world
terms, infectious diarrhea is a leading cause of death in children and can be prevented by
improvements in water quality, home hygiene, sewage disposal and food handling - all
features that affluent communities take for granted.
Water and electrolyte loss is the major cause of death when diarrhea is severe -
frequent watery bowel movements can dehydrate and infant and small child quickly. Both
sodium and potassium are lost and should be replaced. The treatment is oral dehydration
(ORT) - the simplest solution is water as a 0.9 % salt solution by mouth. Commercial
products such as pedialyte are used as ORT. Rice water has been effective in third world
countries - rice is boiled in large amounts of water ( 6 cups per 1 cup of rice) and the
liquid is poured off and fed to the child.
Maxim water absorption occurs when the sodium concentration is 40-90mmol/L and glucose
contrition is 110-140mmol/L; the total osmolalility of the solution should be 290mOsm/L.
Cola for example has an osmolality of 750 mOsm/L; undiluted apple-juice is 730 mOsm/L -
both are too concentrated to feed to a child
Tolerance for Foods
The gastrointestinal tract in normal circumstances learns to tolerate foods that are
presented regularly. Oral tolerance to food is learned by infants as solid foods are
introduced. In the best case, tolerance to regularly eaten food endures throughout the
life of the individual. Infants do best on breast milk for the first six months and
develop tolerance to solid foods if the are introduced slowly over the next six months.
Some infants are hypersensitive and feeding them is difficult; their tolerance mechanisms
do not work very well or are slow to accept new foods. These infants must be fed very
carefully and their breast-feeding mothers often have to follow a careful diet to avoid
food antigens in the breast milk. More permissive tolerance may not show up until the
second year and may be limited for the entire life of that individual.
Many events alter or reduce food tolerance. An infectious gastroenteritis, for example,
may leave the gastrointestinal tract in a hypersensitivity state and the patient reports
decreased tolerance to many foods. This post-infectious hypersensitivity may lead to
chronic "reactive bowel" symptoms.
Gastrointestinal Allergies to Food
In a review of gastrointestinal allergies to food, Walker-Smith and his
colleagues stated that:
"Gastrointestinal food allergies may be defined as clinical syndrome which are
characterized by the onset of gastrointestinal symptoms following food ingestion where the
underlying mechanism is an immunologically mediated reaction within the gastrointestinal
tract.
"There are broadly speaking two categories of clinical syndromes which are related
to the speed of onset of symptoms: immediate and delayed. Those syndromes which manifest
immediately after food ingestion are easy to diagnose and specific IgE tests and prick
tests are frequently positive. Those with a delayed onset of up to several days are
difficult to diagnose and currently available investigations may be unsatisfactory for
routine use."
Saavedra-Delagado and Metcalfe reviewed mechanisms of food antigens causing
gastrointestinal disease. They detailed the pattern of cow's milk induced
gastroenteropathy in children, another prototype of food allergic disease, which
manifests as chronic diarrhea and is not associated with positive skin tests to cow's milk
proteins. They noted associated symptoms included chronic rhinitis and recurrent otitis
media.
Moon and Kleinman reviewed allergic gastroenteropathy in children and stated; "The
symptoms of allergic gastroenteropathy may be those of classic allergic reactions or
present as symptom complexes that may include diarrhea, malabsorption and protein-losing
enteropathy." Diarrhea, vomiting, weight loss, abdominal pain and rectal bleeding
were the dominate symptoms.
Protein-losing enteropathy occurs in children presents as edema, anemia, and growth
failure or weight loss. Food allergy will also cause a non-specific malabsorption syndrome
associated with chronic diarrhea. Following an infectious gastroenteritis, both viral and
bacterial, hypersensitivity reactions to food are common and in infants may present as a
post-enteritis milk-protein intolerance.
Ciprandi and Canonica reported that 132 of 236 patients with cutaneous manifestations
of food allergy had gastrointestinal diseases - 17.8% presenting with irritable bowel,
13.5 % with constipation, and 11% with ulcer-like dyspepsia.
Hill and Milla reported thirteen infants with eosinophilic colitis who improved with
diet revision. All presented with chronic diarrhea containing bloody mucus before 2 years
of age. Colon erythema was noted and biopsies showed inflammatory cell infiltrates in the
lamina propria; eosinophils and plasma cells predominated. Cows milk and eggs were
routinely excluded from the diet with improvement; 7 children did well on soya formula,
but 5 required a chicken-based formula. With food introduction, 7 children developed
diarrhea with other foods; beef (3), wheat (3), white flour (1), fish (2), pork (2) and
goats milk (1).
Hill et al reported milk allergy in children with cystic fibrosis who continued to have
diarrhea and failure to thrive despite adequate treatment with pancreatic enzymes. A
proximal small intestine biopsy was used to identify children with milk enteropathy -
thinning of the mucosa with reduced villous height were the main findings. They estimated
the incidence of milk allergy at 16% in a group of children with cystic fibrosis. The
hydrolysed casein formula, Pregestamil, was used as a milk replacement
Chronic Diarrhea
Some children present with loose and more frequent stools either constantly or
intermittently over months to years. Some have episodes of watery stools with urgency,
cramps, and bloating. Others have low grade but persistent diarrhea. The differential
diagnosis is broad. If weight loss and iron deficiency anemia accompany the diarrhea,
Crohn's and Celiac disease must be considered. Diarrhea with blood in the stools always
suggests ulcerative colitis. Stool samples for cultures and microscopic examination are
essential. The practical point is that most patients with chronic diarrhea will benefit
from diet revision. Diet revision will be definitive treatment especially if
investigations are negative and no specific remedy can be found. By doing careful diet
revision, parents will usually reveal that the child has normal stools with "safe
foods" and will generate a list of reactive foods that trigger recurrent diarrhea.
Constipation
Many children present with chronic constipation with and without episodes of diarrhea.
Reduced stool frequency and hard stools are associated with various degrees of abdominal
discomfort - usually bloating and distention of the descending colon with accumulating
feces.
Diet revision with Alpha Nutrition will often improve bowel function especially if high
vegetable and fruit fiber intake is encouraged. Rice tends to be constipating and this
effect is balanced by having 2-3 portions of vegetables for each portion of rice. Cow's
milk is a major cause of chronic constipation, beginning in infancy. Iacono et al reported
that 21 of 27 infants with chronic constipation improved with a milk protein-free diet; 15
of these infants had evidence of milk allergy.
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